Excel Scientific AdvanceSeal™ 3000 AS-3000L Peelable Foil Heat Seal — Roll Format, 115mm × 500m

Product Description

The Excel Scientific AdvanceSeal™ 3000 AS-3000L is a peelable aluminum foil heat seal in a wide roll format — engineered for PCR, long-term compound storage, light-sensitive assays, and robotic plate sealing workflows requiring a clean, tear-free peel every time. The AS-3000L roll measures 115mm × 500m and is compatible with Kbiosystems, Azenta, and Agilent PlateLoc heat sealers. The wider 115mm format accommodates larger plate formats and sealing platforms requiring greater seal width coverage than the standard 77.5mm roll. Effective across an exceptional temperature range of -80°C to +105°C, and PCR certified free of detectable DNase, RNase, and Human DNA contamination. A narrower 77.5mm × 610m format is also available as AS-3000P.

Peelable Foil — Clean Removal Without Tearing The defining feature of the AdvanceSeal™ 3000 is its peelable design. Unlike standard foil heat seals that must be pierced or cut for sample access, the AS-3000L peels cleanly from the plate without tearing — preserving the integrity of the seal film and preventing foil fragments from contaminating wells during removal. This makes the AdvanceSeal™ 3000 ideal for workflows requiring clean, reliable peel performance in automated and manual plate handling environments.

115mm Wide Format — For Larger Plates and Sealing Platforms The AS-3000L's 115mm width accommodates sealing platforms and plate formats that require a wider roll than the standard AS-3000P (77.5mm). The 500m roll length provides extended run time between roll changes in high-throughput environments — reducing downtime and operator intervention in automated workflows. If your sealer or plate format requires the wider 115mm width, the AS-3000L is the correct format to specify.

AS-3000P vs. AS-3000L — Choosing the Right Roll Width:

Broad Plate Compatibility — Polypropylene, Dual Component, and Polystyrene The AS-3000L is compatible with three common plate substrate types, covering the vast majority of microplates used in PCR, compound storage, and high-throughput screening:

• Polypropylene plates — 3 seconds at 155°C–165°C
• Dual component PCR plates (Polycarbonate/Polypropylene) — 3 seconds at 155°C–165°C
• Polystyrene plates — 2 seconds at 140°C

Sealing parameters should be optimized based on plate type to obtain a secure seal.

Compatible Heat Sealers The AS-3000L is designed for use with the following heat sealers:

• Kbiosystems heat sealers
• Azenta heat sealers
• Agilent PlateLoc heat sealers

-80°C to +105°C Temperature Range — From Deep Freeze to Thermal Cycling The AdvanceSeal™ 3000 maintains a secure, reliable seal across an exceptional operating temperature range of -80°C to +105°C — making it suitable for a broad spectrum of applications in a single roll. Use it to seal plates destined for ultra-low temperature storage at -80°C, for PCR and qPCR thermal cycling, for room-temperature incubation workflows, and for sample plates moving between temperature conditions throughout a workflow. The consistent seal performance across this range eliminates the need to stock separate seals for cold storage vs. thermal cycling applications.

PCR Certified — DNase-Free, RNase-Free, Human DNA-Free The AS-3000L is PCR certified and tested to be free of detectable levels of DNase, RNase, and Human DNA contamination — meeting the quality standards required for nucleic acid amplification workflows where seal-derived contamination could generate false positive results or interfere with amplification efficiency. This certification is critical for clinical, diagnostic, and forensic PCR applications where human DNA contamination from a seal film would be unacceptable.

Excellent Chemical Resistance The foil construction of the AS-3000L provides excellent chemical resistance — making it suitable for sealing plates containing organic solvents, DMSO-based compound libraries, detergent-containing buffers, and other chemically aggressive sample matrices commonly encountered in drug discovery and compound storage workflows.

Light-Sensitive Assay Applications The opaque aluminum foil construction of the AS-3000L provides complete light exclusion — protecting photosensitive compounds, fluorescent dyes, luminescent reagents, and light-sensitive biological samples from photodegradation during storage and incubation. This makes the AS-3000L the appropriate choice over transparent film seals for any workflow involving light-sensitive materials.

Robotic and Automated Platform Compatible The AS-3000L roll format is designed for use with automated heat sealing platforms in robotic liquid handling and high-throughput screening environments. The 115mm width and 500m roll length ensure reproducible sealing operations and extended run time in high-volume automated workflows.

Available AdvanceSeal™ 3000 Formats:

Key Features

• Peelable foil heat seal — removes from plates without tearing
• Wide roll format: 115mm × 500m
• Compatible with Kbiosystems, Azenta, and Agilent PlateLoc heat sealers
• Compatible with polypropylene, dual component (polycarbonate/polypropylene), and polystyrene plates
• Temperature range: -80°C to +105°C
• PCR certified — free of detectable DNase, RNase, and Human DNA
• Excellent chemical resistance — suitable for DMSO, solvents, and aggressive buffers
• Opaque foil — complete light exclusion for photosensitive applications
• Suitable for robotics and automated sealing platforms
• Applications: PCR, qPCR, long-term compound storage, light-sensitive assays, robotics

Recommended Sealing Parameters:

Sealing parameters should be optimized based on plate type to obtain a secure seal.

Supported Applications PCR and qPCR plate sealing, long-term compound library storage at -80°C, light-sensitive assay plate sealing (fluorescence, luminescence, photosensitive compound storage), high-throughput screening, automated robotic plate sealing, DMSO compound library plate sealing, drug discovery compound storage, and any microplate workflow requiring a wide-format peelable foil heat seal with broad temperature range performance.

Technical Specifications