Falcon® 353078 | 48-Well Clear Flat Bottom TC-Treated Cell Culture Plate with Lid, Individually Wrapped, Sterile — 50/Case

The Falcon® 353078 is a 48-well clear flat-bottom TC-treated cell culture plate with lid — sterile, individually wrapped in peel-open medical-style packaging, and featuring a suite of premium design elements that directly improve cell culture performance and contamination control. Flat bottom, with low evaporation lid. Individually wrapped, sterile, 50/case. Unique labyrinth lid, condensation rings, and deep-well design control contamination, reduce evaporation, and minimize edge effects. Reliable vacuum-gas plasma tissue culture treatment provides well-to-well and plate-to-plate consistency. Crystal-grade virgin polystyrene. Nonpyrogenic.  0.75cm² growth area per well. Maximum well capacity: 1.4mL. Working volume: 1.5–2.2mL media / 0.1–0.2mL trypsin. 6 × 8 array. 50 plates per case.

Unique Labyrinth Lid — Superior Contamination Control Unique labyrinth lid, condensation rings, and deep-well design control contamination, reduce evaporation, and minimize edge effects. The Falcon labyrinth lid is the defining premium feature that differentiates the 353078 from standard 48-well plate lid designs. The labyrinth structure creates a tortuous path between the plate interior and the external environment — significantly reducing the probability of airborne contamination reaching the well contents during incubation compared to simple flat or ridged lid designs. The labyrinth geometry forces any contaminating particle or microorganism to navigate multiple directional changes before reaching the wells, providing a meaningful additional barrier of protection without requiring a hermetically sealed lid that would prevent gas exchange.

Condensation Rings — Prevent Drip-Back Contamination The condensation rings molded into the lid interior capture and hold condensation droplets that form on the lid surface during incubation — preventing condensation from dripping back into wells and cross-contaminating samples. In incubator environments where temperature differentials cause significant condensation on lid surfaces, drip-back contamination is a recognized source of well-to-well cross-contamination and media pH disruption. The condensation rings of the Falcon 353078 lid address this directly.

Deep-Well Design — Minimizes Edge Effects Deep-well design control contamination, reduce evaporation, and minimize edge effects. The 48-well format is particularly susceptible to edge effects — the differential evaporation and temperature variation between outer-rim wells and interior wells that causes systematic well-position-dependent variability in cell growth, reagent concentration, and assay readouts. The deep-well design of the 353078 reduces evaporation from individual wells and promotes more uniform temperature and humidity conditions across the plate — minimizing the edge effect that compromises data quality in multi-well plate assays.

Vacuum-Gas Plasma TC Treatment — Well-to-Well and Plate-to-Plate Consistency Reliable vacuum-gas plasma tissue culture treatment provides well-to-well and plate-to-plate consistency. The vacuum-gas plasma TC treatment of the 353078 creates a uniformly hydrophilic, negatively charged surface across the flat bottom of all 48 wells simultaneously — the same surface modification process used across the Falcon cell culture plate line. The process uniformity is tightly controlled, producing equivalent surface chemistry in every well across every plate — critical for multi-condition comparative experiments where well-to-well and plate-to-plate consistency in cell attachment and growth directly determines the quality and reproducibility of experimental results.

0.75cm² Per Well — Optimally Sized for the 48-Well Format The 0.75cm² growth area per well of the 353078 provides more than twice the growth area of a standard 96-well plate (0.33cm²/well) — delivering meaningfully more cell mass per condition for downstream analysis while maintaining the 48-condition throughput of the plate format. At a maximum well capacity of 1.4mL and a working volume of 1.5–2.2mL for media and 0.1–0.2mL for trypsin, the 353078 is optimally configured for the cell density and media volume requirements of standard adherent cell culture at the 48-well scale.

Crystal-Grade Virgin Polystyrene — Optical Clarity for Direct Microscopic Monitoring Crystal-grade virgin polystyrene. The crystal-grade polystyrene construction of the 353078 provides the highest level of optical transparency available in polystyrene cell culture plates — allowing direct observation of cell morphology, confluency, and health under an inverted microscope without removing the plate from the incubator. Crystal-grade polystyrene is a step above standard polystyrene in optical clarity — particularly important for the 48-well format where monitoring individual well contents under the microscope is a routine workflow step.

Individually Wrapped — Peel-Open Medical-Style Packaging Convenient, peel-open medical-style packaging for individual product presentation. Each 353078 plate is individually wrapped in peel-open medical-style packaging — maintaining sterility until the moment of use while providing a clean, professional opening experience at the biosafety cabinet. The peel-open format allows the plate to be opened and introduced to the BSC in a single motion without requiring scissors, tearing, or contamination of the plate surface during unpacking. Individual and Ready-Stack (RS) trays are PET (Code 1) and recyclable. 

Nonpyrogenic — Tested for Endotoxin Content Nonpyrogenic. Every 353078 is tested for pyrogenicity — qualifying it for cell culture applications where endotoxin contamination from the plate material would affect cell viability, immune cell activation, or downstream assay sensitivity. The nonpyrogenic certification is particularly important for primary cell culture, immune cell assays, and any application where cells are sensitive to endotoxin stimulation.

Gamma Irradiation Sterile Sterilised by gamma irradiation. Sterility is achieved by gamma irradiation — providing validated, reliable sterility assurance without residual sterilant concerns associated with ethylene oxide sterilization.

Compatible Replacement — Cross-Reference Guide

The Falcon® 353078 is a direct compatible replacement for 48-well TC-treated flat-bottom cell culture plates from several major manufacturers:

• Thermo Fisher Nunc™ 150687 — Nunc 48-well flat bottom plate with lid, sterile
• Greiner Bio-One 677180 — 48-well TC-treated flat bottom plate with lid, sterile
• Sarstedt 83.3923 — 48-well cell culture plate with lid, TC-treated, sterile
• CELLTREAT 229147 — 48-well TC-treated flat bottom plate with lid, sterile

Competitor brand names and catalog numbers are referenced for cross-referencing purposes only. Compatibility should be verified for your specific application and protocol.

Complete Falcon® Multi-Well Cell Culture Plate Family — Key Formats:

Key Features

• 48-well clear flat-bottom TC-treated cell culture plate with lid
• Unique labyrinth lid — superior contamination control vs. standard lid designs
• Condensation rings — prevent condensation drip-back into wells
• Deep-well design — minimizes edge effects and reduces evaporation
• Vacuum-gas plasma TC treatment — well-to-well and plate-to-plate consistency
• 0.75cm² growth area per well — more than 2× the area of 96-well plates
• Maximum well capacity: 1.4mL
• Working volume: 1.5–2.2mL media / 0.1–0.2mL trypsin
• Crystal-grade virgin polystyrene — exceptional optical clarity
• 6 × 8 array
• Nonpyrogenic — endotoxin tested
• Sterile — gamma irradiation
• Individually wrapped in peel-open medical-style packaging
• Individual and RS trays are PET (Code 1) and recyclable
• Corning EcoChoice™ — renewable energy manufacturing
• 50 plates per case

Supported Applications Adherent cell culture at 48-well scale, dose-response and IC&sub5;&sub0; studies requiring more cell mass than 96-well format, multi-condition cytotoxicity assays, primary cell culture across many conditions, gene expression studies requiring sufficient cell harvest, protein extraction for Western blotting, transfection efficiency across multiple conditions, viral infection at multiple MOI, compound screening at low-to-medium throughput, cell-based reporter assays, and any mammalian cell culture application requiring the 48-well flat-bottom TC-treated format with premium labyrinth lid contamination control.

Technical Specifications