MTC Bio OptiWell™ Tip Comb D3340-24 | 24-Tip V-Bottom, Polypropylene, Non-Sterile — 50/Pack (25 Bags of 2)

Product Description

The MTC Bio OptiWell™ Tip Comb D3340-24 is a 24-tip V-bottom polypropylene tip comb — designed for magnetic bead-based nucleic acid and protein affinity purification in automated extraction systems including KingFisher™ Flex and Accuris IsoPure™ extraction systems. Can be used for viral RNA extraction, DNA extraction, immunoprecipitation, and quantification. Made of chemically inert, low binding virgin polypropylene. Certified RNase-free, DNase-free, and pyrogen-free. Non-sterile. Pack of 50 tip combs — 25 bags of 2 per pack. Catalog # D3340-24.

What Is a Tip Comb? — Essential Component for Magnetic Bead Extraction A tip comb is the magnetic tip array insert used in automated magnetic bead-based nucleic acid and protein extraction workflows — the consumable component that interfaces directly between the magnetic head of an automated extraction instrument (KingFisher™, Accuris IsoPure™, and similar platforms) and the sample wells of the deep well plate. During automated extraction, the instrument lowers the tip comb into sample-containing wells, magnetizes through the tip comb tips to capture magnetic beads, transfers beads across wash buffer wells, and releases them into elution buffer — all without requiring manual pipetting. The tip comb is a single-use consumable that is discarded after each extraction run to prevent cross-contamination between samples.

24-Tip Format — For 24-Sample Extraction Runs The 24-tip format of the D3340-24 processes 24 samples simultaneously per extraction run — matching the standard 24-sample processing capacity of the KingFisher™ Flex and Accuris IsoPure™ platforms in single-row or partial-plate extraction mode. For labs running smaller batches of 24 samples or fewer per extraction run, the 24-tip comb is the correct format — consuming fewer reagents per run than a 96-tip comb while maintaining the full automation benefit of the magnetic bead extraction workflow.

V-Bottom Tip Geometry — Optimized for Efficient Bead Collection The V-bottom tip geometry of the D3340-24 is specifically designed to work with V-bottom deep well plates — concentrating magnetic beads at the lowest point of each well for complete bead collection by the magnetic tip during the capture step. The V-bottom tip profile matches the conical geometry of the well bottom to minimize the gap between tip and well base — ensuring that even small bead quantities are fully captured without leaving beads stranded in the well corners. For labs using OptiWell™ V-bottom deep well plates (D3096-07, D3096-07S, D3096-09, D3096-09S, D3096-19, D3096-19S, D3096-23, D3096-23S, D3096-45, D3096-45S) in their extraction workflow, the D3340-24 V-bottom tip comb is the correctly matched consumable.

KingFisher™ Flex and Accuris IsoPure™ Compatible Compatible with automated systems including KingFisher™ Flex and Accuris IsoPure™ extraction systems. The D3340-24 OptiWell™ Tip Comb is validated for use with the two most widely deployed automated magnetic bead extraction platforms in laboratory settings — providing a cost-effective alternative to OEM tip combs from these instrument manufacturers without sacrificing extraction performance. For labs running KingFisher™ Flex or Accuris IsoPure™ instruments and seeking to reduce per-run consumable costs, the D3340-24 provides a validated alternative tip comb for the 24-tip extraction format.

Low Binding Virgin Polypropylene — Minimal Sample Loss Made of chemically inert, low binding virgin polypropylene. The low binding polypropylene formulation of the D3340-24 minimizes non-specific adsorption of nucleic acids, proteins, and magnetic beads to the tip comb surface — ensuring that sample molecules are carried efficiently by the magnetic beads rather than being lost to tip comb surface binding. The chemically inert polypropylene material is compatible with the full range of lysis buffers, wash buffers, and elution buffers used in magnetic bead extraction protocols without leaching plasticizers or other chemical contaminants into the eluate.

Certified RNase-Free, DNase-Free, and Pyrogen-Free Certified RNase, DNase and pyrogen free. The D3340-24 meets the molecular biology grade purity standards required for nucleic acid extraction applications — eliminating the risk of RNA and DNA degradation from nuclease contamination and pyrogen-mediated assay interference. For viral RNA extraction workflows where RNA integrity is critical for downstream RT-qPCR and sequencing applications, the RNase-free certification is a critical quality requirement.

Paired with OptiWell™ Deep Well Plates — Complete Extraction System The D3340-24 tip comb is designed to work in conjunction with OptiWell™ deep well plates as a complete automated extraction system. For V-bottom tip comb applications, the compatible OptiWell™ plate formats include:

Pack of 50 — 25 Bags of 2 for Contamination-Free Storage Pack of 50 ea (25 bags of 2ea). The dual-comb per bag packaging of the D3340-24 ensures that tip combs are stored in a sealed, protected environment until use — with each bag providing exactly one pair of tip combs for clean, contamination-controlled dispensing. This packaging format prevents dust accumulation and physical damage to the tip comb tips during storage while minimizing packaging waste per tip comb consumed.

Compatible Replacement — Cross-Reference Guide

The MTC Bio OptiWell™ Tip Comb D3340-24 is a compatible alternative to OEM tip combs from several major automated extraction instrument manufacturers:

• Thermo Fisher KingFisher™ Flex Tip Comb, 24-tip (97003534) — OEM 24-tip comb for KingFisher™ Flex
• Thermo Fisher KingFisher™ Duo Tip Comb, 24-tip — OEM 24-tip comb for KingFisher™ Duo
• Accuris IsoPure™ Tip Comb, 24-tip — OEM 24-tip comb for IsoPure™

The D3340-24 is validated as a compatible alternative to OEM tip combs for the listed platforms. Compatibility should be confirmed for your specific instrument firmware version and extraction protocol. Competitor brand names are referenced for cross-referencing purposes only.

Key Features

• MTC Bio OptiWell™ Tip Comb — Catalog # D3340-24
• 24-tip format — processes 24 samples simultaneously per extraction run
• V-bottom tip geometry — matched for V-bottom deep well plate formats
• Compatible with KingFisher™ Flex and Accuris IsoPure™ extraction systems
• Low binding virgin polypropylene — chemically inert, minimal sample loss
• Certified RNase-free, DNase-free, and pyrogen-free
• Non-sterile
• Pack of 50 tip combs — 25 bags of 2 per pack
• Sigma-Aldrich catalog # MTCD334024
• Single-use — discard after each extraction run to prevent cross-contamination

Supported Applications Magnetic bead-based DNA extraction, viral RNA extraction and purification, total RNA extraction from biological samples, immunoprecipitation and protein affinity purification, nucleic acid quantification sample preparation, cell-free DNA and cfRNA extraction, SARS-CoV-2 and other viral nucleic acid extraction, environmental sample nucleic acid extraction, food safety nucleic acid testing, pharmaceutical QC nucleic acid extraction, and any automated magnetic bead-based extraction workflow requiring 24-tip V-bottom tip combs for KingFisher™ Flex or Accuris IsoPure™ platforms.

Technical Specifications