MTC Bio OptiWell™ Tip Comb D3340-24S | 24-Tip V-Bottom, Polypropylene, Sterile — 50/Pack (25 Bags of 2)

Product Description

The MTC Bio OptiWell™ Tip Comb D3340-24S is a sterile 24-tip V-bottom polypropylene tip comb — designed for magnetic bead-based nucleic acid and protein affinity purification in automated extraction systems including KingFisher™ Flex and Accuris IsoPure™ extraction systems. Can be used for viral RNA extraction, DNA extraction, immunoprecipitation, and quantification. Made of chemically inert, low binding virgin polypropylene. Certified RNase-free, DNase-free, and pyrogen-free. Sterile. Pack of 50 tip combs — 25 bags of 2 per pack. Catalog # D3340-24S.

D3340-24S vs. D3340-24 — Sterile vs. Non-Sterile: The Only Difference The D3340-24S and D3340-24 are identical OptiWell™ 24-tip V-bottom tip combs in every way — sterility is the sole difference:

The D3340-24S sterile format is the correct choice for labs whose 24-sample extraction workflows require validated sterile consumables — including clinical diagnostic nucleic acid extraction, GMP-compliant pharmaceutical testing, sterile cell-free DNA/RNA extraction, and any regulated application where sterile tip combs are specified in the standard operating procedure. For standard research workflows where sterility is not required, the more economical D3340-24 is the appropriate choice.

D3340-24S vs. D3340-96S — 24-Tip vs. 96-Tip Sterile: Choosing the Right Format The D3340-24S and D3340-96S are identical sterile V-bottom tip combs — the number of tips is the sole difference:

The D3340-24S is the correct sterile format for labs running smaller sterile extraction batches of 24 samples or fewer — consuming fewer reagents per run and matching the throughput of 24-well processing protocols. For full 96-sample sterile extraction runs, the D3340-96S is the appropriate format.

24-Tip Format — Sterile Processing for Smaller Batch Sizes The 24-tip format of the D3340-24S processes 24 samples simultaneously per extraction run in sterile format — the ideal configuration for clinical labs, pharmaceutical QC facilities, and regulated testing environments that run smaller sterile extraction batches. For regulated workflows where sterility is required but extraction volume does not justify a full 96-sample run, the D3340-24S provides validated sterile extraction at 24-sample throughput with lower per-run reagent consumption.

When Sterile 24-Tip Combs Are Required The D3340-24S sterile format is specifically needed in several application contexts:

• Clinical diagnostic labs — processing smaller daily batches of 24 or fewer patient samples in sterile extraction format for diagnostic nucleic acid testing
• GMP pharmaceutical QC — sterile nucleic acid extraction for pharmaceutical quality control testing at batch sizes matching 24-well processing
• Cell-free nucleic acid extraction — cfDNA and cfRNA liquid biopsy extraction from small patient sample cohorts requiring sterile consumables
• Validated method development — developing and validating sterile extraction SOPs at 24-sample scale before scaling to 96-sample sterile workflows
• BSL-controlled viral RNA extraction — sterile extraction of viral RNA from small batches of infectious samples in biosafety-controlled environments

V-Bottom Tip Geometry — Complete Bead Collection from V-Bottom Plates The V-bottom tip geometry of the D3340-24S is specifically designed to work with V-bottom deep well plates — concentrating magnetic beads at the lowest point of each well for complete bead collection by the magnetic tip array. For sterile 24-sample extraction workflows, the D3340-24S is paired with the corresponding sterile V-bottom OptiWell™ deep well plates:

KingFisher™ Flex and Accuris IsoPure™ Compatible — Sterile 24-Tip Format Compatible with automated systems including KingFisher™ Flex and Accuris IsoPure™ extraction systems. The D3340-24S provides a validated sterile alternative to OEM sterile 24-tip combs from these instrument manufacturers — maintaining full instrument compatibility for sterile 24-sample extraction runs at competitive pricing.

Low Binding Virgin Polypropylene — Sterile and Chemically Inert Made of chemically inert, low binding virgin polypropylene. The sterile D3340-24S maintains the same low binding surface properties as the non-sterile D3340-24 — sterility does not compromise the low binding characteristics of the polypropylene material across all 24 tip positions.

Certified RNase-Free, DNase-Free, and Pyrogen-Free Certified RNase, DNase and pyrogen free. The D3340-24S carries the same nuclease-free and pyrogen-free certifications as the D3340-24 — in addition to validated sterility. For sterile clinical RNA extraction workflows where nuclease contamination from tip combs would degrade RNA samples and compromise diagnostic results, the combined RNase-free and sterile certifications are both essential.

50 Pack — 25 Bags of 2 for Sterile Storage Pack of 50 ea (25 bags of 2ea). Matching the pack size of the non-sterile D3340-24, the D3340-24S provides 50 sterile tip combs per pack — in individual 2-per-bag packaging that maintains sterility until use while allowing clean, controlled dispensing of individual tip combs for each extraction run.

Compatible Replacement — Cross-Reference Guide

The MTC Bio OptiWell™ Tip Comb D3340-24S is a compatible alternative to sterile OEM 24-tip combs from several major automated extraction instrument manufacturers:

• Thermo Fisher KingFisher™ Flex Tip Comb, 24-tip, Sterile — OEM sterile 24-tip comb for KingFisher™ Flex
• Thermo Fisher KingFisher™ Duo Tip Comb, 24-tip, Sterile — OEM sterile 24-tip comb for KingFisher™ Duo
• Accuris IsoPure™ Tip Comb, 24-tip, Sterile — OEM sterile 24-tip comb for IsoPure™

The D3340-24S is validated as a compatible sterile alternative to OEM tip combs for the listed platforms. Compatibility should be confirmed for your specific instrument firmware version and extraction protocol. Competitor brand names are referenced for cross-referencing purposes only.

Key Features

• MTC Bio OptiWell™ Tip Comb — Catalog # D3340-24S
• 24-tip format — sterile processing for 24-sample extraction runs
• V-bottom tip geometry — matched for V-bottom deep well plate formats
• Sterile — gamma irradiation validated sterility
• Compatible with KingFisher™ Flex and Accuris IsoPure™ extraction systems
• Low binding virgin polypropylene — chemically inert, minimal sample loss
• Certified RNase-free, DNase-free, and pyrogen-free
• Pack of 50 tip combs — 25 bags of 2 per pack
• Sigma-Aldrich catalog # MTCD334024S
• Single-use — discard after each extraction run to prevent cross-contamination
• Non-sterile 24-tip version: D3340-24
• Sterile 96-tip version: D3340-96S

Supported Applications Clinical diagnostic nucleic acid extraction of 24-sample batches requiring sterile consumables, GMP pharmaceutical nucleic acid QC testing at 24-sample scale, cell-free DNA and cfRNA liquid biopsy extraction from small patient cohorts, sterile viral RNA extraction from small batches of infectious samples in BSL-controlled environments, regulated pharmaceutical environmental monitoring at 24-sample scale, sterile method development and SOP validation at 24-tip format, sterile immunoprecipitation and protein affinity purification at 24-sample scale, and any automated magnetic bead-based extraction workflow requiring sterile 24-tip V-bottom tip combs for KingFisher™ Flex or Accuris IsoPure™ platforms.

Technical Specifications