MTC Bio OptiWell™ Tip Comb D3340-96S | 96-Tip V-Bottom, Polypropylene, Sterile — 100/Pack (50 Bags of 2)

Product Description

The MTC Bio OptiWell™ Tip Comb D3340-96S is a sterile 96-tip V-bottom polypropylene tip comb — designed for magnetic bead-based nucleic acid and protein affinity purification in automated extraction systems including KingFisher™ Flex and Accuris IsoPure™ extraction systems. Can be used for viral RNA extraction, DNA extraction, immunoprecipitation, and quantification. Made of chemically inert, low binding virgin polypropylene. Certified RNase-free, DNase-free, and pyrogen-free. Sterile. Pack of 100 tip combs — 50 bags of 2 per pack. Catalog # D3340-96S.

D3340-96S vs. D3340-96 — Sterile vs. Non-Sterile: The Only Difference The D3340-96S and D3340-96 are identical OptiWell™ 96-tip V-bottom tip combs in every way — sterility is the sole difference:

The D3340-96S sterile format is the correct choice for labs whose extraction workflows require validated sterile consumables — including clinical diagnostic nucleic acid extraction, GMP-compliant pharmaceutical nucleic acid testing, sterile cell-free DNA/RNA extraction, and any regulated application where sterile tip combs are specified in the standard operating procedure. For standard research extraction workflows where sterility is not required, the more economical D3340-96 is the appropriate choice.

When Sterile Tip Combs Are Required The sterility of the D3340-96S matters most in several specific application contexts:

• Clinical diagnostic workflows — clinical laboratory accreditation standards may specify sterile consumables for diagnostic nucleic acid extraction to prevent environmental contamination of clinical samples
• GMP pharmaceutical manufacturing — pharmaceutical nucleic acid extraction performed under GMP conditions specifies sterile consumables to meet regulatory compliance requirements
• Cell-free nucleic acid extraction — cfDNA, cfRNA, and liquid biopsy workflows involve trace nucleic acid detection from plasma and serum where background contamination from non-sterile consumables can affect analytical sensitivity
• Viral RNA extraction in BSL environments — biosafety-controlled extraction workflows for infectious samples may specify sterile tip combs as part of contamination control SOPs
• Regulated environmental monitoring — pharmaceutical environmental monitoring workflows that specify sterile sampling consumables throughout the workflow

96-Tip Format — Full Plate Throughput in Sterile Format The 96-tip format of the D3340-96S processes all 96 samples of a standard deep well plate simultaneously per extraction run — maintaining the full throughput advantage of the 96-tip format while adding validated sterility. For high-volume sterile extraction workflows where both throughput and sterility are required simultaneously, the D3340-96S provides the optimal combination.

V-Bottom Tip Geometry — Optimized for V-Bottom Deep Well Plates The V-bottom tip geometry of the D3340-96S is specifically designed to work with V-bottom deep well plates — concentrating magnetic beads at the lowest point of each well for complete bead collection by the magnetic tip array during the capture step. Compatible OptiWell™ V-bottom plate formats include all sterile V-bottom plates in the lineup:

KingFisher™ Flex and Accuris IsoPure™ Compatible — Sterile Format Compatible with automated systems including KingFisher™ Flex and Accuris IsoPure™ extraction systems. The D3340-96S provides a validated sterile alternative to OEM sterile tip combs from these instrument manufacturers — maintaining full instrument compatibility while offering competitive pricing for sterile tip comb consumables.

Low Binding Virgin Polypropylene — Sterile and Chemically Inert Made of chemically inert, low binding virgin polypropylene. The sterile D3340-96S maintains the same low binding surface properties as the non-sterile D3340-96 — sterility does not compromise the low binding characteristics of the polypropylene material. The combination of sterile surface and low binding formulation ensures that both sterility and extraction yield performance are maintained across all 96 tip positions.

Certified RNase-Free, DNase-Free, and Pyrogen-Free Certified RNase, DNase and pyrogen free. The D3340-96S carries the same nuclease-free and pyrogen-free certifications as the D3340-96 — in addition to the sterility certification. For sterile clinical RNA extraction workflows where nuclease contamination from tip combs would degrade RNA samples and compromise diagnostic results, the RNase-free certification of the D3340-96S is especially critical.

100 Pack — Maximum Supply for High-Throughput Sterile Extraction Pack of 100 ea (50 bags of 2ea). At 100 sterile tip combs per pack, the D3340-96S matches the pack size of the non-sterile D3340-96 — providing the same supply efficiency for high-throughput sterile extraction workflows. For labs running multiple sterile 96-sample extraction batches per day, the 100-pack format reduces reorder frequency.

Compatible Replacement — Cross-Reference Guide

The MTC Bio OptiWell™ Tip Comb D3340-96S is a compatible alternative to sterile OEM 96-tip combs from several major automated extraction instrument manufacturers:

• Thermo Fisher KingFisher™ Flex Tip Comb, 96-tip, Sterile — OEM sterile 96-tip comb for KingFisher™ Flex
• Thermo Fisher KingFisher™ Duo Prime Tip Comb, 96-tip, Sterile — OEM sterile 96-tip comb for KingFisher™ Duo Prime
• Accuris IsoPure™ Tip Comb, 96-tip, Sterile — OEM sterile 96-tip comb for IsoPure™

The D3340-96S is validated as a compatible sterile alternative to OEM tip combs for the listed platforms. Compatibility should be confirmed for your specific instrument firmware version and extraction protocol. Competitor brand names are referenced for cross-referencing purposes only.

Key Features

• MTC Bio OptiWell™ Tip Comb — Catalog # D3340-96S
• 96-tip format — full plate throughput, processes all 96 samples simultaneously
• V-bottom tip geometry — matched for V-bottom deep well plate formats
• Sterile — gamma irradiation validated sterility
• Compatible with KingFisher™ Flex and Accuris IsoPure™ extraction systems
• Low binding virgin polypropylene — chemically inert, minimal sample loss across all 96 tips
• Certified RNase-free, DNase-free, and pyrogen-free
• Pack of 100 tip combs — 50 bags of 2 per pack
• Sigma-Aldrich catalog # MTCD334096S
• Single-use — discard after each extraction run to prevent cross-contamination
• Non-sterile 96-tip version: D3340-96
• Sterile 24-tip version: D3340-24S (if available)

Supported Applications Clinical diagnostic nucleic acid extraction requiring sterile consumables, GMP pharmaceutical nucleic acid extraction, cell-free DNA (cfDNA) and cell-free RNA extraction from plasma and serum, viral RNA extraction in BSL-controlled environments, regulated pharmaceutical environmental monitoring, high-throughput sterile DNA extraction from full 96-well plates, high-throughput sterile viral RNA extraction, sterile immunoprecipitation and protein affinity purification in full plate format, and any automated magnetic bead-based extraction workflow requiring sterile 96-tip V-bottom tip combs for KingFisher™ Flex or Accuris IsoPure™ platforms.

Technical Specifications